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Developed an artificial synapse connector that reconnects broken neural circuits-A new way to treat psychiatric and neurological disorders caused by synaptic abnormalities-

         published in  "Science"

Hiroyuki Sasakura, Assistant Professor of Biology, Aichi Medical University, Professor Tsunesei Takeuchi, and the German Center for Neurodegenerative Diseases, Oxford University, UK, and MRC Institute for Molecular Biology are led by Professor Tsusuke Yuzuzaki, Department of Physiology, Keio University School of Medicine. In the international collaborative research team, we succeeded for the first time in the world in developing an artificial protein (synaptic connector) that can artificially form synapses, which are the joints between nerve cells, and quickly reconnect broken neural circuits. .. Using this synaptic connector, we succeeded in leading significant functional improvement and recovery in model animals of cerebellar ataxia, Alzheimer's disease, and spinal cord injury.
For details, please see here (press release) and the science site .


Leding seeds to pharmaceutical companies through "search for spinal cord injury therapeutic agents with nerve regeneration promoting action"

The Japan Agency for Medical Research and Development (AMED) Drug Discovery Strategy Department has discussed the 2019 activity status of the "Drug Discovery Support Network" that supports the creation of innovative drugs. We reported that we have out-licensed seeds from "Search for therapeutic agents" to pharmaceutical companies.
In a drug development project that inhibits the action of enzymes that hinder the recovery of spinal cord injury, we decided to outsource to a pharmaceutical company through a public offering. AMED's seeds out-licensing by this business is the 7th in total, and it is a successful example of out-licensing in all 120 themes.
The theme derived this year is "Search for a drug for treating spinal cord injury that promotes nerve regeneration" (Professor Tsunesei Takeuchi, Aichi Medical University School of Medicine).
For details, please see External Site 1 and External Site 2 .


Research results on the importance of chondroitin sulfate for the formation of "maxillofacial region" and "skin suppleness"

It has been pointed out that chondroitin sulfate is important for the formation of cartilage and bones of limbs. This chondroitin sulfate is important for the formation of maxillofacial and head bones and the suppleness of the skin, and is also involved in the expression and correct arrangement of collagen that supports these tissues and organs. We were the first in the world to discover that it is extremely important for the formation of external organizations. Please see here for details.

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